{"id":177,"date":"2026-08-25T22:20:00","date_gmt":"2026-08-25T20:20:00","guid":{"rendered":"https:\/\/www.veyronalabs.com\/?post_type=product&#038;p=177"},"modified":"2026-10-14T23:24:08","modified_gmt":"2026-10-14T21:24:08","slug":"kpv-10-mg","status":"publish","type":"product","link":"https:\/\/www.veyronalabs.com\/es\/product\/kpv-10-mg\/","title":{"rendered":"KPV 10 mg"},"content":{"rendered":"<style>\n<p>.vl-premium{--gold:#c99a2e;--soft:#f7f0df;--ink:#15171a;--muted:#62666d;--line:#e7e2d8;max-width:1180px;margin:38px auto 0;color:var(--ink);font-family:inherit}.vl-premium *{box-sizing:border-box}.vl-premium h2,.vl-premium h3,.vl-premium h4{color:var(--ink);letter-spacing:-.02em}.vl-premium h2{font-size:clamp(30px,4vw,46px);margin:0 0 12px}.vl-premium h3{font-size:clamp(23px,3vw,31px);margin:0 0 18px}.vl-premium h4{font-size:18px;margin:0 0 8px}.vl-premium p{line-height:1.72}.vl-premium 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0}.vl-grid4,.vl-grid3,.vl-grid2,.vl-trust{grid-template-columns:1fr}.vl-card,.vl-panel,.vl-lab{padding:22px}.vl-lead{font-size:17px}}<\/p>\n<p>.vl-tech{margin-top:28px;border:1px solid rgba(201,154,46,.42);border-radius:18px;overflow:hidden;background:#111318;color:#fff;box-shadow:0 14px 36px rgba(17,19,24,.13)}\n.vl-tech-head{display:flex;justify-content:space-between;align-items:flex-end;gap:24px;padding:20px 22px;border-bottom:1px solid rgba(201,154,46,.30);background:linear-gradient(135deg,#0d0f13,#171a20)}\n.vl-tech-head span{color:#d7ae4f;font-size:12px;font-weight:800;letter-spacing:.13em;text-transform:uppercase}\n.vl-tech-head strong{color:#d9dce2;font-size:13px;font-weight:600;text-align:right}\n.vl-tech-body{background:#14171c}\n.vl-tech-row{display:grid;grid-template-columns:minmax(155px,.72fr) minmax(0,1.55fr);gap:24px;padding:15px 22px;border-bottom:1px solid rgba(255,255,255,.09)}\n.vl-tech-row:last-child{border-bottom:0}\n.vl-tech-row span{color:#d7ae4f;font-size:13px;font-weight:750}\n.vl-tech-row strong{color:#f5f5f6;font-size:14px;font-weight:600;line-height:1.55;overflow-wrap:anywhere}\n@media(max-width:680px){.vl-tech-head{display:block;padding:18px 16px}.vl-tech-head strong{display:block;margin-top:6px;text-align:left;font-size:12px}.vl-tech-row{grid-template-columns:1fr;gap:4px;padding:13px 16px}.vl-tech-row span{font-size:11px;letter-spacing:.04em;text-transform:uppercase}.vl-tech-row strong{font-size:13px}}\n<\/style>\n<div class=\"vl-premium\">\n<section class=\"vl-hero\">\n<div class=\"vl-eye\">Trip\u00e9ptido derivado de \u03b1-MSH \u00b7 Lys-Pro-Val<\/div>\n<h2>KPV 10 mg<\/h2>\n<p class=\"vl-lead\">P\u00e9ptido de tres amino\u00e1cidos suministrado para la investigaci\u00f3n de laboratorio controlada sobre la se\u00f1alizaci\u00f3n inflamatoria, la biolog\u00eda de la barrera epitelial y los sistemas de transporte de p\u00e9ptidos intestinales.<\/p>\n<div class=\"vl-tech\" aria-label=\"Datos t\u00e9cnicos del producto\">\n<div class=\"vl-tech-head\"><span>Datos t\u00e9cnicos del producto<\/span><strong>Calidad e identidad de un vistazo<\/strong><\/div>\n<div class=\"vl-tech-body\">\n<div class=\"vl-tech-row\"><span>Pureza \/ an\u00e1lisis<\/span><strong>Determinado por lote en el informe de laboratorio correspondiente.<\/strong><\/div>\n<div class=\"vl-tech-row\"><span>Forma f\u00edsica<\/span><strong>Material de investigaci\u00f3n de p\u00e9ptidos liofilizados<\/strong><\/div>\n<div class=\"vl-tech-row\"><span>Contenido declarado<\/span><strong>10 mg<\/strong><\/div>\n<div class=\"vl-tech-row\"><span>Embalaje<\/span><strong>1 vial de laboratorio sellado<\/strong><\/div>\n<div class=\"vl-tech-row\"><span>Tipo de p\u00e9ptido<\/span><strong>trip\u00e9ptido; fragmento \u03b1-MSH 11-13<\/strong><\/div>\n<div class=\"vl-tech-row\"><span>Secuencia<\/span><strong>Lys\u2013Pro\u2013Val (KPV)<\/strong><\/div>\n<div class=\"vl-tech-row\"><span>F\u00f3rmula molecular<\/span><strong>C16H30N4O4<\/strong><\/div>\n<div class=\"vl-tech-row\"><span>Peso molecular<\/span><strong>342,44 g\/mol<\/strong><\/div>\n<div class=\"vl-tech-row\"><span>N\u00famero CAS<\/span><strong>67727-97-3<\/strong><\/div>\n<div class=\"vl-tech-row\"><span>Almacenamiento: polvo sin abrir<\/span><strong>Conserve el vial liofilizado sellado a -20 \u00b0C, en un lugar seco y protegido de la luz. Deje que el vial cerrado alcance la temperatura ambiente antes de abrirlo para evitar la condensaci\u00f3n.<\/strong><\/div>\n<div class=\"vl-tech-row\"><span>Almacenamiento \u2014 despu\u00e9s de mezclar con agua BAC<\/span><strong>Tras su preparaci\u00f3n con agua bacteriost\u00e1tica, conservar refrigerado a 2\u20138 \u00b0C y protegido de la luz. No congelar; minimizar los ciclos repetidos de calentamiento y enfriamiento.<\/strong><\/div>\n<div class=\"vl-tech-row\"><span>Solubilidad \/ reconstituci\u00f3n<\/span><strong>Agua bacteriost\u00e1tica: 1 ml por vial<\/strong><\/div>\n<\/div>\n<\/div>\n<\/section>\n<section class=\"vl-sec\">\n<div class=\"vl-eye\">\u00c1reas de investigaci\u00f3n<\/div>\n<h3>Donde se est\u00e1 investigando a KPV<\/h3>\n<div class=\"vl-grid4\">\n<article class=\"vl-card\"><span class=\"vl-num\">01<\/span><\/p>\n<h4>Se\u00f1alizaci\u00f3n inflamatoria<\/h4>\n<p>Respuestas asociadas a NF-\u03baB y expresi\u00f3n de citoquinas en sistemas experimentales.<\/p>\n<\/article>\n<article class=\"vl-card\"><span class=\"vl-num\">02<\/span><\/p>\n<h4>Epitelio intestinal<\/h4>\n<p>Integridad de la barrera intestinal, respuestas de las c\u00e9lulas col\u00f3nicas y modelos experimentales de colitis.<\/p>\n<\/article>\n<article class=\"vl-card\"><span class=\"vl-num\">03<\/span><\/p>\n<h4>Transporte de p\u00e9ptidos<\/h4>\n<p>Captaci\u00f3n mediada por PepT1 y administraci\u00f3n dirigida en modelos epiteliales.<\/p>\n<\/article>\n<article class=\"vl-card\"><span class=\"vl-num\">04<\/span><\/p>\n<h4>Biolog\u00eda de la piel<\/h4>\n<p>Investigaci\u00f3n sobre queratinocitos y respuesta inflamatoria en modelos cut\u00e1neos.<\/p>\n<\/article>\n<\/div>\n<\/section>\n<section class=\"vl-sec\">\n<div class=\"vl-split\">\n<div class=\"vl-panel\">\n<div class=\"vl-eye\">Antecedentes cient\u00edficos<\/div>\n<h3>\u00bfQu\u00e9 es KPV?<\/h3>\n<p>KPV es el trip\u00e9ptido lisina-prolina-valina, que corresponde al fragmento C-terminal de la hormona estimulante de los melanocitos \u03b1 (\u03b1-MSH 11-13). A diferencia de la hormona completa, KPV carece del n\u00facleo cl\u00e1sico de uni\u00f3n al receptor de melanocortina y se estudia por su actividad antiinflamatoria, que podr\u00eda implicar v\u00edas independientes del receptor.<\/p>\n<p>La mayor\u00eda de las publicaciones cient\u00edficas utilizan c\u00e9lulas epiteliales cultivadas o modelos animales de inflamaci\u00f3n intestinal. La formulaci\u00f3n y la administraci\u00f3n son cuestiones fundamentales en la investigaci\u00f3n, ya que la exposici\u00f3n local, el transporte y la estabilidad de un p\u00e9ptido corto pueden influir considerablemente en los resultados experimentales.<\/p>\n<\/div>\n<div class=\"vl-panel vl-gold\">\n<div class=\"vl-eye\">Mapa de evidencias<\/div>\n<h4>Lo que respalda la literatura<\/h4>\n<p>Estudios celulares y en roedores respaldan la investigaci\u00f3n de KPV como modulador de la se\u00f1alizaci\u00f3n inflamatoria, particularmente en sistemas epiteliales intestinales. Se ha explorado el transporte de PepT1 y la administraci\u00f3n mediante nanopart\u00edculas o polisac\u00e1ridos para aumentar la exposici\u00f3n local en el colon.<\/p>\n<h4>Direcci\u00f3n actual de la investigaci\u00f3n<\/h4>\n<p>Modelos epiteliales humanos, administraci\u00f3n dirigida y estudios traslacionales cuidadosamente dise\u00f1ados.<\/p>\n<\/div>\n<\/div>\n<\/section>\n<section class=\"vl-sec\">\n<div class=\"vl-eye\">Mecanismo de acci\u00f3n<\/div>\n<h3>Rutas biol\u00f3gicas propuestas<\/h3>\n<div class=\"vl-grid3 vl-mech\">\n<article class=\"vl-card\"><span class=\"vl-tag\">NF-\u03baB<\/span><\/p>\n<h4>Transcripci\u00f3n inflamatoria<\/h4>\n<p>Los estudios celulares informan de una activaci\u00f3n reducida de los programas inflamatorios asociados a NF-\u03baB y una menor expresi\u00f3n de determinados mediadores proinflamatorios bajo estimulaci\u00f3n experimental.<\/p>\n<\/article>\n<article class=\"vl-card\"><span class=\"vl-tag\">PepT1<\/span><\/p>\n<h4>Transporte epitelial<\/h4>\n<p>Se ha investigado el transportador intestinal de oligop\u00e9ptidos PepT1 como v\u00eda de captaci\u00f3n celular, lo que ayuda a explicar por qu\u00e9 la estrategia de administraci\u00f3n modifica la actividad experimental local.<\/p>\n<\/article>\n<article class=\"vl-card\"><span class=\"vl-tag\">fragmento \u03b1-MSH<\/span><\/p>\n<h4>Biolog\u00eda independiente de receptores<\/h4>\n<p>El KPV conserva su actividad antiinflamatoria sin la secuencia completa de melanocortina, lo que respalda la investigaci\u00f3n de mecanismos que no requieren la activaci\u00f3n convencional del receptor de melanocortina.<\/p>\n<\/article>\n<\/div>\n<\/section>\n<section class=\"vl-sec\">\n<div class=\"vl-eye\">Revisi\u00f3n de la evidencia<\/div>\n<h3>\u00bfQu\u00e9 revelan las investigaciones?<\/h3>\n<div class=\"vl-grid2\">\n<article class=\"vl-card\"><span class=\"vl-tag\">modelos celulares<\/span><\/p>\n<h4>Respuestas inflamatorias del colon<\/h4>\n<p>Los experimentos realizados con c\u00e9lulas epiteliales del colon humano revelaron una atenuaci\u00f3n de la se\u00f1alizaci\u00f3n inflamatoria tras la exposici\u00f3n al KPV, incluidos efectos relacionados con el transporte de PepT1.<\/p>\n<\/article>\n<article class=\"vl-card\"><span class=\"vl-tag\">modelos animales<\/span><\/p>\n<h4>Colitis experimental<\/h4>\n<p>Estudios sobre la colitis en roedores que utilizaron sistemas de administraci\u00f3n oral dirigidos reportaron reducciones en los marcadores de la enfermedad y la inflamaci\u00f3n. Los resultados dependen del modelo y la formulaci\u00f3n.<\/p>\n<\/article>\n<article class=\"vl-card\"><span class=\"vl-tag\">Ciencia de la entrega<\/span><\/p>\n<h4>Nanopart\u00edculas dirigidas al colon<\/h4>\n<p>Se han estudiado sistemas portadores de \u00e1cido hialur\u00f3nico y polisac\u00e1ridos para proteger la exposici\u00f3n al KPV y concentrarla en el tejido col\u00f3nico inflamado.<\/p>\n<\/article>\n<article class=\"vl-card\"><span class=\"vl-tag\">Etapa de investigaci\u00f3n<\/span><\/p>\n<h4>Mapa de evidencia precl\u00ednica<\/h4>\n<p>Los estudios celulares y en animales sientan las bases para continuar trabajando en el transporte, la formulaci\u00f3n y la se\u00f1alizaci\u00f3n de KPV.<\/p>\n<\/article>\n<\/div>\n<\/section>\n<section class=\"vl-sec\">\n<div class=\"vl-split\" style=\"grid-template-columns:1fr\">\n<div class=\"vl-panel\">\n<div class=\"vl-eye\">Investigaci\u00f3n y publicaciones<\/div>\n<h3>Lecturas seleccionadas<\/h3>\n<ul class=\"vl-pubs\">\n<li><strong><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/18061175\/\" target=\"_blank\" rel=\"noopener\">Actividad antiinflamatoria de KPV en c\u00e9lulas epiteliales intestinales<\/a><\/strong><span>Investigaci\u00f3n sobre c\u00e9lulas y colitis asociadas a PepT1 \u00b7 PubMed<\/span><\/li>\n<li><strong><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28143741\/\" target=\"_blank\" rel=\"noopener\">Administraci\u00f3n oral dirigida de KPV mediante nanopart\u00edculas de \u00e1cido hialur\u00f3nico.<\/a><\/strong><span>Investigaci\u00f3n sobre la administraci\u00f3n experimental dirigida al colon \u00b7 PubMed<\/span><\/li>\n<li><strong><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22465151\/\" target=\"_blank\" rel=\"noopener\">Nanopart\u00edculas cargadas con KPV en colitis experimental<\/a><\/strong><span>Investigaci\u00f3n precl\u00ednica sobre inflamaci\u00f3n intestinal \u00b7 PubMed<\/span><\/li>\n<\/ul>\n<\/div>\n<\/div>\n<\/section>\n<section class=\"vl-sec\">\n<div class=\"vl-lab\"><span class=\"vl-tag\">Pruebas de laboratorio independientes<\/span><\/p>\n<h3>Documentaci\u00f3n espec\u00edfica del lote<\/h3>\n<p>Utilice el identificador de lote que figura en el vial para localizar el informe anal\u00edtico correspondiente en la biblioteca de resultados de Veyrona Labs. Los informes publicados presentan la identidad espec\u00edfica del lote, la pureza, el contenido medido y los resultados de endotoxinas, cuando se han realizado las pruebas.<\/p>\n<p><a href=\"\/es\/resultados-de-laboratorio-2\/\"><strong>Ver la biblioteca de resultados de Veyrona Labs \u2192<\/strong><\/a><\/p>\n<\/div>\n<div class=\"vl-status\">\n<div class=\"vl-eye\">Aviso sobre el uso en investigaci\u00f3n<\/div>\n<p>Solo para investigaci\u00f3n de laboratorio y an\u00e1lisis. No apto para uso humano ni veterinario.<\/p>\n<\/div>\n<\/section><\/div>","protected":false},"excerpt":{"rendered":"<p><strong>Un peque\u00f1o p\u00e9ptido de investigaci\u00f3n estudiado en la se\u00f1alizaci\u00f3n inflamatoria y los tejidos de barrera.<\/strong><\/p>\n<p>KPV es un fragmento corto relacionado con la alfa-MSH. Los investigadores lo estudian principalmente en modelos que involucran el intestino, la piel y las v\u00edas de respuesta inmunitaria.<\/p>\n<p><strong>\u00c1reas de investigaci\u00f3n:<\/strong> Se\u00f1alizaci\u00f3n inflamatoria \u00b7 Barrera intestinal \u00b7 Biolog\u00eda de la piel<\/p>","protected":false},"featured_media":221,"comment_status":"open","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}}},"product_brand":[],"product_cat":[29,18,30],"product_tag":[],"class_list":["post-177","product","type-product","status-publish","has-post-thumbnail","product_cat-recovery-immune-research","product_cat-research-peptides","product_cat-skin-appearance-research","desktop-align-center","tablet-align-center","mobile-align-left","first","instock","shipping-taxable","purchasable","product-type-simple"],"_links":{"self":[{"href":"https:\/\/www.veyronalabs.com\/es\/wp-json\/wp\/v2\/product\/177","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.veyronalabs.com\/es\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/www.veyronalabs.com\/es\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/www.veyronalabs.com\/es\/wp-json\/wp\/v2\/comments?post=177"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.veyronalabs.com\/es\/wp-json\/wp\/v2\/media\/221"}],"wp:attachment":[{"href":"https:\/\/www.veyronalabs.com\/es\/wp-json\/wp\/v2\/media?parent=177"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/www.veyronalabs.com\/es\/wp-json\/wp\/v2\/product_brand?post=177"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/www.veyronalabs.com\/es\/wp-json\/wp\/v2\/product_cat?post=177"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/www.veyronalabs.com\/es\/wp-json\/wp\/v2\/product_tag?post=177"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}